Two-Stranded α-Helical Coiled-Coils of Fibrous Proteins
نویسندگان
چکیده
منابع مشابه
α/β coiled coils
Coiled coils are the best-understood protein fold, as their backbone structure can uniquely be described by parametric equations. This level of understanding has allowed their manipulation in unprecedented detail. They do not seem a likely source of surprises, yet we describe here the unexpected formation of a new type of fiber by the simple insertion of two or six residues into the underlying ...
متن کاملHelix-Coil Transitions of a-Helical, Two-Chain, Coiled Coils
A theory of the helix-coil transition for in-register, two-chain, a-helical, coiled coils such as tropomyosin and paramyosin is developed. The treatment differs from those formulated previously for DNAor collagen-like double helices; in the present treatment, isolated single chains and each of the two strands in the dimer may be partially helical. We calculate the fraction of helix in the two-c...
متن کاملMechanical transition from α-helical coiled coils to β-sheets in fibrin(ogen).
We characterized the α-to-β transition in α-helical coiled-coil connectors of the human fibrin(ogen) molecule using biomolecular simulations of their forced elongation and theoretical modeling. The force (F)-extension (X) profiles show three distinct regimes: (1) the elastic regime, in which the coiled coils act as entropic springs (F < 100-125 pN; X < 7-8 nm); (2) the constant-force plastic re...
متن کاملElectrostatic determinants of stability in parallel 3-stranded coiled coils.
The optimal positioning of salt-bridging interactions in a parallel alpha-helical homotrimeric coiled coil has been explored in a metal ion-assembled polypeptide trimer of 60 residues; arginine-glutamate pairs are more stabilizing than the corresponding lysine-glutamate pairs, and optimal stabilization is obtained with positively charged arginine residues at the c positions of the alpha-helical...
متن کاملDynamic allostery of protein alpha helical coiled-coils.
Alpha helical coiled-coils appear in many important allosteric proteins such as the dynein molecular motor and bacteria chemotaxis transmembrane receptors. As a mechanism for transmitting the information of ligand binding to a distant site across an allosteric protein, an alternative to conformational change in the mean static structure is an induced change in the pattern of the internal dynami...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1986
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(86)83601-3